Comprehensive Profiling of Circular RNAs in Goat Dermal Papilla Cells and Prediction of Their Modulatory Roles in Hair Growth

Circular RNAs (circRNAs) are capable of finely modulating gene expression at transcriptional and post-transcriptional levels; however, their characters in dermal papilla cells (DPCs)—the signaling center hair follicle—are still obscure. Herein, we established a comprehensive atlas circRNAs DPCs skin counterparts—dermal fibroblasts (DFs)—from cashmere goats. In terms the results, sum 3706 were bioinformatically identified. Subsequent analysis suggested that detected transcripts exhibited several prominent genomic features, including exons as main sources. Compared with DFs, 76 significantly displayed higher abundances goat DPCs, 45 markedly exhibiting adverse trends (p < 0.05). Furthermore, potential roles underlying molecular mechanisms speculated through constructing possible regulatory networks mRNAs microRNAs (miRNAs). We found may serve miRNA sponges to alleviate three growth-related functional genes (HOXC8, RSPO1, CCBE1) from miRNAs-imposed modulation, further facilitating two critical processes (HOXC8 RSPO1: follicle stem cell activation; CCBE1: follicular angiogenesis) closely involved growth. addition, also intron-derived (chi_circ_0005569 chi_circ_0005570) possibly affect host CCBE1 level nucleus. The above results demonstrated abundantly expressed certain participators growth via effects on levels related genes. Our study offers preliminary clue for researchers hoping untangle non-coding